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Dutasteride (brand name Avodart) is a 5-alpha reductase inhibitor originally approved by the FDA for benign prostatic hyperplasia, an enlarged prostate condition

105 Hyperglycemia initiates a positive feedback loop involving the tyrosine kinase ErbB4 and the mammalian target of rapamycin (mTOR), contributing to tau hyperphosphorylation under hyperglycemic conditions

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This hypothesis might have been corroborated by the observation that the levels of the cleaved forms of caspase-3 and PARP, both proteins which may be associated with programmed cell death, seemed to be reduced after introduction of AHK-Cu